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公开(公告)号：US10543232B2
公开(公告)日：2020-01-28
申请号：US16297133
申请日：2019-03-08
发明人： Alex Levitzki , Salim Joubran , Alexei Shir , Maya Zigler , Alaa Talhami , Yael Langut
摘要： A polyplex of a double stranded RNA (dsRNA) and a polymeric conjugate consists of a linear polyethyleneimine (PEI) covalently linked to one or more polyethylene glycol (PEG) moieties. Each PEG moiety is conjugated via a linker to a targeting moiety capable of binding to a cancer antigen. Exemplary cancer antigens include epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2) and prostate surface membrane antigen (PSMA).
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公开(公告)号：US10278991B2
公开(公告)日：2019-05-07
申请号：US15310735
申请日：2015-05-14
发明人： Alex Levitzki , Salim Joubran , Alexei Shir , Maya Zigler , Alaa Talhami , Yael Langut
摘要： A polyplex of a double stranded RNA and a polymeric conjugate is provided, wherein the polymeric conjugate consists of a linear polyethyleneimine covalently linked to one or more polyethylene glycol (PEG) moieties, each PEG moiety being conjugated via a linker to a targeting moiety capable of binding to a cancer antigen.
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公开(公告)号：US20190262395A1
公开(公告)日：2019-08-29
申请号：US16296117
申请日：2019-03-07
发明人： Alex Levitzki , Salim Joubran , Alexei Shir , Maya Zigler , Alaa Talhami , Yael Langut
IPC分类号： A61K35/14 , C12N15/117 , A61K47/59 , A61K47/60 , A61K45/06
摘要： A method of treating cancer can include administering a polyplex of a double stranded RNA and a polymeric conjugate. The polymeric conjugate can consist of a linear polyethyleneimine covalently linked to one or more polyethylene glycol (PEG) moieties. Each PEG moiety can be conjugated via a linker to a targeting moiety capable of binding to a cancer antigen.
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公开(公告)号：US20190192563A1
公开(公告)日：2019-06-27
申请号：US16297133
申请日：2019-03-08
发明人： Alex Levitzki , Salim Joubran , Alexei Shir , Maya Zigler , Alaa Talhami , Yael Langut
IPC分类号： A61K35/14 , C12N15/117 , A61K47/59 , A61K47/60 , A61K45/06
摘要： A polyplex of a double stranded RNA (dsRNA) and a polymeric conjugate consists of a linear polyethyleneimine (PEI) covalently linked to one or more polyethylene glycol (PEG) moieties. Each PEG moiety is conjugated via a linker to a targeting moiety capable of binding to a cancer antigen. Exemplary cancer antigens include epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2) and prostate surface membrane antigen (PSMA).
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公开(公告)号：US20220339189A1
公开(公告)日：2022-10-27
申请号：US17653221
申请日：2022-03-02
发明人： Alex Levitzki , Salim Joubran , Alexei Shir , Maya Zigler , Alaa Talhami , Yael Langut
IPC分类号： A61K35/14 , A61K45/06 , C12N15/117 , A61K47/60 , A61K47/59
摘要： A method of treating cancer may include administering a polyplex of a double stranded RNA and a polymeric conjugate. The polymeric conjugate may consist of a linear polyethyleneimine covalently linked to one or more polyethylene glycol (PEG) moieties. Each PEG moiety may be conjugated via a linker to a targeting moiety capable of binding to a cancer antigen.
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公开(公告)号：US11298376B2
公开(公告)日：2022-04-12
申请号：US16296117
申请日：2019-03-07
发明人： Alex Levitzki , Salim Joubran , Alexei Shir , Maya Zigler , Alaa Talhami , Yael Langut
摘要： A method of treating cancer can include administering a polyplex of a double stranded RNA and a polymeric conjugate. The polymeric conjugate can consist of a linear polyethyleneimine covalently linked to one or more polyethylene glycol (PEG) moieties. Each PEG moiety can be conjugated via a linker to a targeting moiety capable of binding to a cancer antigen.
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