Technologies for trusted I/O (TIO) include a computing device with a cryptographic engine and one or more I/O controllers. The computing device executes a TIO core service that has a cryptographic engine programming privileged granted by an operating system. The TIO core service receives a request from an application to protect a DMA channel. The TIO core service requests the operating system to protect the DMA channel, and the operating system verifies the cryptographic engine programming privilege of the TIO core service in response. The operating system programs the cryptographic engine to protect the DMA channel in response to verifying the cryptographic engine programming privilege of the TIO core service. If a privileged delegate determines that a user has confirmed termination of protection of the DMA channel, the TIO core service may unprotect the DMA channel. Other embodiments are described and claimed.