An electronic device and a method of operating the electronic device using a gamma voltage of a display panel are provided. The electronic device includes a display panel, and a display driver integrated circuit. The display driver integrated circuit includes a source driver including source amplifiers to amplify output signals to be output through sub-pixels included in each pixel of the display panel, a gamma voltage output circuit that outputs one or more gamma voltages for correcting gray scales of the output signals depending on characteristics of the sub-pixels, a gamma adjustment circuit that provides reference voltages for the gamma voltages to the gamma voltage output circuit and includes signal lines connected with the gamma voltage output circuit, and switches connected between the signal lines.