Systems, methods, and apparatus for optimizing bus latency associated with a serial bus using staggered bidirectional transmission within a transaction or datagram are described. A method performed at a device coupled to a serial bus includes initiating a transaction between the first device and a second device to exchange a datagram with the second device in a first direction over the serial bus, and exchanging one or more bytes of data with the second device in a second direction over the serial bus before the datagram has been completely transmitted. The first device and the second device alternate as transmitters on the serial bus such that direction of data transmission is staggered on the serial bus. The serial bus may be operated in accordance with an I3C, RFFE, SPMI, or other protocol.