- 专利标题： Substituted triazolopiperazine PARP inhibitor, preparation method therefor and use thereof
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申请号： US15987458申请日： 2018-05-23
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公开(公告)号： US10597399B2公开(公告)日： 2020-03-24
- 发明人: Ao Zhang , Zehong Miao , Pingyuan Wang , Shanshan Song , Zilan Song , Xiajuan Huan , Zhoulong Fan , Jian Ding
- 申请人： Ao Zhang , Zehong Miao , Pingyuan Wang , Shanshan Song , Zilan Song , Xiajuan Huan , Zhoulong Fan , Jian Ding
- 申请人地址： CN Shanghai
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人地址： CN Shanghai
- 代理机构： Reinhart Boerner Van Deuren P.C.
- 优先权： CN201510818057 20151123
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/444 ; A61K31/437 ; A61K31/502 ; C07D471/04 ; A61K31/4985 ; A61P35/00
摘要：
A class of substituted triazolopiperazine compounds represented by formula (I), tautomers, enantiomers, diastereomers, racemates, metabolites, metabolic precursors, and pharmaceutically acceptable salts, esters, prodrugs or hydrate thereof, a preparation methods therefor, intermediates and a use thereof in the preparation of drugs for prevention and treatment of diseases associated with PARP including various ischemic diseases, neurodegenerative diseases and cancers.
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