公开(公告)号：US20180265516A1

公开(公告)日：2018-09-20

申请号：US15987458

申请日：2018-05-23

申请人： Ao Zhang ,  Zehong Miao ,  Pingyuan Wang ,  Shanshan Song ,  Zilan Song ,  Xiajuan Huan ,  Zhoulong Fan ,  Jian Ding

发明人： Ao Zhang ,  Zehong Miao ,  Pingyuan Wang ,  Shanshan Song ,  Zilan Song ,  Xiajuan Huan ,  Zhoulong Fan ,  Jian Ding

IPC分类号： C07D487/04 ,  A61P35/00

摘要： The present invention relates to a class of substituted triazolopiperazine compounds, tautomers, enantiomers, diastereomers, racemates, metabolites, metabolic precursors, and pharmaceutically acceptable salts, esters, prodrugs or hydrate thereof, a preparation methods therefor, intermediates and a use thereof in the preparation of drugs for prevention and treatment of diseases associated with PARP including various ischemic diseases, neurodegenerative diseases and cancers.

公开(公告)号：US10597399B2

公开(公告)日：2020-03-24

申请号：US15987458

申请日：2018-05-23

申请人： Ao Zhang ,  Zehong Miao ,  Pingyuan Wang ,  Shanshan Song ,  Zilan Song ,  Xiajuan Huan ,  Zhoulong Fan ,  Jian Ding

发明人： Ao Zhang ,  Zehong Miao ,  Pingyuan Wang ,  Shanshan Song ,  Zilan Song ,  Xiajuan Huan ,  Zhoulong Fan ,  Jian Ding

IPC分类号： C07D487/04 ,  A61K31/444 ,  A61K31/437 ,  A61K31/502 ,  C07D471/04 ,  A61K31/4985 ,  A61P35/00

摘要： A class of substituted triazolopiperazine compounds represented by formula (I), tautomers, enantiomers, diastereomers, racemates, metabolites, metabolic precursors, and pharmaceutically acceptable salts, esters, prodrugs or hydrate thereof, a preparation methods therefor, intermediates and a use thereof in the preparation of drugs for prevention and treatment of diseases associated with PARP including various ischemic diseases, neurodegenerative diseases and cancers.

公开(公告)号：US07271173B2

公开(公告)日：2007-09-18

申请号：US10716100

申请日：2003-11-18

申请人： John L. Neumeyer ,  Ao Zhang

发明人： John L. Neumeyer ,  Ao Zhang

IPC分类号： A61K31/4365 ,  A61K31/437 ,  C07D221/18

CPC分类号： C07D221/22 ,  C07D221/28 ,  C07D491/08 ,  C07D513/08

摘要： This invention features opioid compounds having activity at kappa and mu receptors, methods for preparing the mu/kappa opioids, and methods for the treatment of pain or a dopamine dysregulation disease, such as schizophrenia, attention deficit hyperactivity disorder (ADHD), attention deficit hyperactivity disorder (ADD), Parkinson's disease, hyperprolactinemia, depression, and addiction.

摘要翻译： 本发明的特征在于具有κ和μ受体活性的阿片样物质，制备μ/κ阿片样物质的方法，以及用于治疗疼痛或多巴胺失调疾病如精神分裂症，注意力缺陷多动障碍（ADHD），注意力缺陷障碍 （ADD），帕金森病，高催乳素血症，抑郁症和成瘾。

公开(公告)号：USD1039276S1

公开(公告)日：2024-08-20

申请号：US29912621

申请日：2023-09-21

申请人： Ao Zhang

设计人： Ao Zhang

摘要： FIG. 1 is a perspective view of our new design.
FIG. 2 is another perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top view thereof; and,
FIG. 8 is a bottom view thereof.
The broken lines in the drawings depict portions of the article and form no part of the claim.