公开(公告)号：US10597399B2

公开(公告)日：2020-03-24

申请号：US15987458

申请日：2018-05-23

申请人： Ao Zhang ,  Zehong Miao ,  Pingyuan Wang ,  Shanshan Song ,  Zilan Song ,  Xiajuan Huan ,  Zhoulong Fan ,  Jian Ding

发明人： Ao Zhang ,  Zehong Miao ,  Pingyuan Wang ,  Shanshan Song ,  Zilan Song ,  Xiajuan Huan ,  Zhoulong Fan ,  Jian Ding

IPC分类号： C07D487/04 ,  A61K31/444 ,  A61K31/437 ,  A61K31/502 ,  C07D471/04 ,  A61K31/4985 ,  A61P35/00

摘要： A class of substituted triazolopiperazine compounds represented by formula (I), tautomers, enantiomers, diastereomers, racemates, metabolites, metabolic precursors, and pharmaceutically acceptable salts, esters, prodrugs or hydrate thereof, a preparation methods therefor, intermediates and a use thereof in the preparation of drugs for prevention and treatment of diseases associated with PARP including various ischemic diseases, neurodegenerative diseases and cancers.

公开(公告)号：US20180265516A1

公开(公告)日：2018-09-20

申请号：US15987458

申请日：2018-05-23

申请人： Ao Zhang ,  Zehong Miao ,  Pingyuan Wang ,  Shanshan Song ,  Zilan Song ,  Xiajuan Huan ,  Zhoulong Fan ,  Jian Ding

发明人： Ao Zhang ,  Zehong Miao ,  Pingyuan Wang ,  Shanshan Song ,  Zilan Song ,  Xiajuan Huan ,  Zhoulong Fan ,  Jian Ding

IPC分类号： C07D487/04 ,  A61P35/00

摘要： The present invention relates to a class of substituted triazolopiperazine compounds, tautomers, enantiomers, diastereomers, racemates, metabolites, metabolic precursors, and pharmaceutically acceptable salts, esters, prodrugs or hydrate thereof, a preparation methods therefor, intermediates and a use thereof in the preparation of drugs for prevention and treatment of diseases associated with PARP including various ischemic diseases, neurodegenerative diseases and cancers.