Invention Grant
- Patent Title: Endostatin mutants with mutations at ATP binding sites
-
Application No.: US14343694Application Date: 2012-09-10
-
Publication No.: US10647968B2Publication Date: 2020-05-12
- Inventor: Yongzhang Luo , Peng Liu , Xinan Lu , Yang Chen , Yan Fu , Guodong Chang , Daifu Zhou
- Applicant: Yongzhang Luo , Peng Liu , Xinan Lu , Yang Chen , Yan Fu , Guodong Chang , Daifu Zhou
- Applicant Address: CN Beijing CN Beijing
- Assignee: Tsinghua University,Beijing Protgen Ltd.
- Current Assignee: Tsinghua University,Beijing Protgen Ltd.
- Current Assignee Address: CN Beijing CN Beijing
- Agency: Rothwell, Figg, Ernst & Manbeck, P.C.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@794f006d
- International Application: PCT/CN2012/081210 WO 20120910
- International Announcement: WO2013/034116 WO 20130314
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C12N9/14 ; C07K14/475 ; C12Q1/00 ; A61K47/60
Abstract:
The present invention discloses a new anti-tumor medicament comprising a mutant of endostatin. The mutant comprises a mutation in the ATP-binding site of endostatin and has a decreased ATPase activity and an increased anti-angiogenesis activity.
Public/Granted literature
- US20150197733A9 ENDOSTATIN MUTANTS WITH MUTATIONS AT ATP BINDING SITES Public/Granted day:2015-07-16
Information query
IPC分类:
