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    USE OF NUCLEOLIN AS A BIOMARKER FOR LYMPHANGIOGENESIS IN CANCER PROGNOSIS AND THERAPY
    5.
    发明申请
    USE OF NUCLEOLIN AS A BIOMARKER FOR LYMPHANGIOGENESIS IN CANCER PROGNOSIS AND THERAPY 审中-公开
    作为生物标记物的核蛋白用于癌症预防和治疗中的淋巴细胞生成

    公开(公告)号：US20130023479A1

    公开(公告)日：2013-01-24

    申请号：US13554913

    申请日：2012-07-20

    Applicant: Yongzhang Luo ,  Wei Zhuo ,  Yan Fu ,  Guodong Chang

    Inventor： Yongzhang Luo ,  Wei Zhuo ,  Yan Fu ,  Guodong Chang

    IPC: G01N33/574 ,  A61K38/17 ,  A61P35/04 ,  C40B30/04

    CPC classification number: G01N33/574 ,  A61K38/39 ,  C07K16/28 ,  C07K2317/76 ,  G01N2333/515 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/7014

    Abstract: The present invention relates to a method of identifying cancer subjects, in particular human patients, who are suitable for anti-lymphangiogenesis therapy to prevent tumor growth and tumor metastasis. The present invention also relates to a new approach, which uses nucleolin as a bait to search and screen for lymphangiogenesis inhibitors or cancer suppressors, which function in a manner that is analogous to endostatin. The invention is based upon the discovery that nucleolin is specifically expressed on lymphangiogenic vessels and functions as a specific receptor for endostatin, and thus is involved in the signal transduction pathway of endostatin as an anti-lymphangiogenesis inhibitor. The present invention also discloses that cell surface nucleolin on lymphatic endothelial cells is a biomarker for lymphangiogenic vessels, which could be used for the prediction of tumor metastasis.

    Abstract translation: 本发明涉及鉴定适合于抗淋巴管生成治疗以预防肿瘤生长和肿瘤转移的癌症受试者，特别是人类患者的方法。 本发明还涉及使用核仁林作为诱饵来搜索和筛选淋巴管生成抑制剂或癌抑制因子的新方法，其以类似于内皮抑素的方式起作用。 本发明基于以下发现：核仁林在淋巴管生成血管上特异性表达，并且作为内皮抑制素的特异性受体起作用，因此参与作为抗淋巴管生成抑制剂的内皮抑素的信号转导途径。 本发明还公开了淋巴管内皮细胞上的细胞表面核仁素是淋巴管生成血管生物标志物，可用于预测肿瘤转移。

    Method and Apparatus for Selecting Network Services
    6.
    发明申请
    Method and Apparatus for Selecting Network Services 有权
    选择网络服务的方法和设备

    公开(公告)号：US20110219127A1

    公开(公告)日：2011-09-08

    申请号：US12716099

    申请日：2010-03-02

    Applicant: Yan Fu

    Inventor： Yan Fu

    IPC: G06F15/16

    CPC classification number: G06F15/16

    Abstract: An approach is provided for selecting a network server. An apparatus comprising at least one processor, and at least one memory including computer program code, the at least one memory and the computer program code configured to, with the at least one processor, cause, at least in part, the apparatus to load from one or more network servers configuration information of one or more network servers used by a service provider network. The apparatus is also caused to select a network server in the service provider network based at least in part on at least one of network server latency and the network server load. The apparatus is further caused to set the network server as default network server used for at least one of current and future session on one or more user equipment.

    Abstract translation: 提供了一种用于选择网络服务器的方法。 一种装置，包括至少一个处理器，以及包括计算机程序代码的至少一个存储器，所述至少一个存储器和所述计算机程序代码被配置为与所述至少一个处理器一起至少部分地使所述装置从 服务提供商网络使用的一个或多个网络服务器的一个或多个网络服务器配置信息。 该设备还被引导以至少部分地基于网络服务器延迟和网络服务器负载中的至少一个来在服务提供商网络中选择网络服务器。 进一步使设备将网络服务器设置为在一个或多个用户设备上用于当前和将来会话中的至少一个的默认网络服务器。

    METHOD AND APPARATUS FOR PROVIDING A SCALABLE SERVICE PLATFORM USING A NETWORK CACHE
    7.
    发明申请
    METHOD AND APPARATUS FOR PROVIDING A SCALABLE SERVICE PLATFORM USING A NETWORK CACHE 有权
    使用网络缓存提供可扩展服务平台的方法和装置

    公开(公告)号：US20100332834A1

    公开(公告)日：2010-12-30

    申请号：US12495071

    申请日：2009-06-30

    Applicant: Yan Fu ,  Ari M. Vepsalainen ,  Ari Antero Aarnio ,  Markku Kalevi Vimpari ,  Pekka Laitinen

    Inventor： Yan Fu ,  Ari M. Vepsalainen ,  Ari Antero Aarnio ,  Markku Kalevi Vimpari ,  Pekka Laitinen

    IPC: H04L9/32 ,  H04L9/08

    CPC classification number: H04L9/08 ,  H04L9/0822 ,  H04L2209/60 ,  H04L2209/80

    Abstract: An approach is provided for building a scalable service platform by initiating transmission of encrypted data from a public network cache. An access control server platform determines a first authorization key for a user and a second authorization key for a resource, and then encrypts the resource with the second authorization key, and encrypts the second authorization key with the first authorization key. The access control server platform initiates distribution of the encrypted second authorization key with the encrypted resource over a network. The access control server platform further initiates caching the encrypted second authorization key with the encrypted resource that meets a predefined threshold value (e.g., a data size, an access frequency, a modification frequency, or an auditing requirement) in a cache in the network, and initiates transmission of the cached and encrypted second authorization key with the cached and encrypted resource from the cache to at least one authorized entity.

    Abstract translation: 提供了一种通过从公共网络缓存发起加密数据来构建可扩展服务平台的方法。 访问控制服务器平台确定用户的第一授权密钥和用于资源的第二授权密钥，然后用第二授权密钥对资源进行加密，并用第一授权密钥加密第二授权密钥。 访问控制服务器平台通过网络启动加密的第二授权密钥与加密的资源的分发。 访问控制服务器平台进一步发起加密的第二授权密钥与加密资源缓存，该加密的资源满足网络中的高速缓存中的预定阈值（例如，数据大小，访问频率，修改频率或审核要求） 并且启动具有缓存和加密的资源的缓存和加密的第二授权密钥从高速缓存传输到至少一个授权实体。

    Method, Device and System for Combination of Resource and Admission Control
    9.
    发明申请
    Method, Device and System for Combination of Resource and Admission Control 有权
    资源和入场控制相结合的方法，装置和系统

    公开(公告)号：US20100114943A1

    公开(公告)日：2010-05-06

    申请号：US12683829

    申请日：2010-01-07

    Applicant: Yan FU ,  Xiaoyu GONG ,  Ting ZOU

    Inventor： Yan FU ,  Xiaoyu GONG ,  Ting ZOU

    IPC: G06F21/00 ,  G06F17/30

    CPC classification number: H04L41/0893 ,  H04L47/70 ,  H04L47/745 ,  H04L47/762 ,  H04L47/824 ,  H04L47/828 ,  H04L63/20

    Abstract: A method, a device and a system for combination of resource admission control are provided. The system includes the policy determination combination device and multiple bearer and transmission devices. The combination device combines functions and interfaces of two or multiple kinds of arbitrary policy determination devices in systems of different standards, and has multiple interfaces to be connected with the bearer and transmission devices, and selects the corresponding interface working protocol according to the type of bearer and transmission device. Multiple bearer and transmission devices are connected with the policy determination combination device by different interfaces. By setting policy determination combination device, the combination of policy determination devices is realized with a few changes to the current network. When there are multiple types of bearer and transmission devices in a management domain, the number of the policy determination devices can be efficiently reduced, and the cost of setting up the network and maintenance can be reduced. Also, it is propitious to collaborate and combine different standards and to improve speed of industrialization.

    Abstract translation: 提供了一种用于组合资源准入控制的方法，装置和系统。 该系统包括策略确定组合设备和多个承载和传输设备。 组合设备将不同标准系统中的两种或多种任意策略确定设备的功能和接口相结合，具有与承载和传输设备连接的多个接口，并根据承载类型选择对应的接口工作协议 和传输设备。 多个承载和传输设备通过不同的接口与策略确定组合设备连接。 通过设置策略确定组合设备，通过对当前网络的几个变化来实现策略确定设备的组合。 当在管理域中存在多种类型的承载和传输设备时，可以有效地减少策略确定设备的数量，并且可以降低建立网络和维护的成本。 此外，有利于合作，结合不同标准，提高工业化进程。

    METHOD AND APPARATUS FOR PUSHING MESSAGES
    10.
    发明申请
    METHOD AND APPARATUS FOR PUSHING MESSAGES 审中-公开
    推送消息的方法和装置

    公开(公告)号：US20100075701A1

    公开(公告)日：2010-03-25

    申请号：US12560793

    申请日：2009-09-16

    Applicant: Mingsheng Shang ,  Yan Fu ,  Gang Shao

    Inventor： Mingsheng Shang ,  Yan Fu ,  Gang Shao

    IPC: H04W4/14

    CPC classification number: G06Q30/02 ,  H04L12/1859 ,  H04L51/38 ,  H04L67/26 ,  H04W4/14

    Abstract: A method for pushing messages includes: categorizing a first information according to a first category set, creating a first mapping relation between the first information and a category in the first category set; categorizing a second information sent by a message source according to a second category set, and creating a second mapping relation between the message source that sends the second information and a category in the second category set; sorting out each category in the second category set that matches the corresponding category in the first category set which is in the first mapping relation with the first information according to the relation between the first category in the first category set and the second category in the second category set, and determining the corresponding message source according to the second mapping relation; and pushing the first information to the determined corresponding message source.

    Abstract translation: 推送消息的方法包括：根据第一类别集分类第一信息，创建第一信息与第一类别集合中的类别之间的第一映射关系; 对根据第二类别集合的消息源发送的第二信息进行分类，并且在发送第二信息的消息源和第二类别集合中的类别之间创建第二映射关系; 根据第一类别集合中的第一类别和第二类别中的第二类别之间的关系，将与第一类别集合的第一类别集合中的与第一信息相匹配的每个类别与第一信息进行排序 类别集，并根据第二映射关系确定相应的消息源; 并将第一信息推送到确定的相应消息源。

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