There are disclosed a system and method for touch and interaction in a three-dimension display, and after a three-dimension touch and interaction mode is enabled, a relative location relationship between a touch position of an operator and a display panel is determined according to transmitting time of ultrasonic signals transmitted by at least two ultrasonic transmitters and receiving time when ultrasonic signals reflected at the touch position of the operator are received by at least two ultrasonic sensors; and then the ultrasonic transmitters are controlled to transmit ultrasonic signals at preset power to the touch position of the operator according to a three-dimension object currently displayed on the display panel and the relative location relationship between the touch position of the operator and the display panel to make feedback for a touch operation at the touch position of the operator.