- 专利标题： Identification of CD8+ T cells that are CD161hi and/or IL18R(α)hi and have rapid drug efflux capacity
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申请号： US15903214申请日： 2018-02-23
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公开(公告)号： US10653756B2公开(公告)日： 2020-05-19
- 发明人: Cameron J. Turtle , Stanley R. Riddell
- 申请人： FRED HUTCHINSON CANCER RESEARCH CENTER
- 申请人地址： US WA Seattle
- 专利权人： Fred Hutchinson Cancer Research Center
- 当前专利权人： Fred Hutchinson Cancer Research Center
- 当前专利权人地址： US WA Seattle
- 代理机构： Seed IP Law Group LLP
- 主分类号： C12N5/0783
- IPC分类号： C12N5/0783 ; A61K39/00 ; G01N33/50 ; A61K35/17
摘要：
This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory CD8+ T cell subsets (CMhi and EMhi) with high surface expression of CD161 and/or IL-18Rα and the capacity to rapidly efflux the fluorescent dye Rh123.
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