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1.发明申请公开(公告)号：US20180243386A1
公开(公告)日：2018-08-30
申请号：US15903214
申请日：2018-02-23
IPC分类号： A61K39/00 , C12N5/0783 , A61K35/17 , G01N33/50
CPC分类号： A61K39/00 , A61K35/17 , A61K2039/515 , A61K2039/57 , A61K2039/572 , C12N5/0636 , C12N5/0638 , C12N2501/599 , G01N33/505 , G01N2333/54 , G01N2333/70557
摘要： This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory CD8+ T cell subsets (CMhi and EMhi) with high surface expression of CD161 and/or IL-18Rα and the capacity to rapidly efflux the fluorescent dye Rh123.
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2.发明申请IDENTIFICATION OF CD8+ T CELLS THAT ARE CD161HI AND/OR IL18R(ALPHA)HI AND HAVE RAPID DRUG EFFLUX CAPACITY 有权鉴定为CD161HI和/或IL18R（ALPHA）HI的CD8 + T细胞，并具有快速的药物吸收能力公开(公告)号：US20160045580A1
公开(公告)日：2016-02-18
申请号：US14810286
申请日：2015-07-27
IPC分类号： A61K39/00
CPC分类号： A61K39/00 , A61K35/17 , A61K2039/515 , A61K2039/57 , A61K2039/572 , C12N5/0636 , C12N5/0638 , C12N2501/599 , G01N33/505 , G01N2333/54 , G01N2333/70557
摘要： This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory CD8+ T cell subsets (CMhi and EMhi) with high surface expression of CD161 and/or IL-18Rα and the capacity to rapidly efflux the fluorescent dye Rh123.
摘要翻译： 本发明尤其提供了用于识别和分离具有高表达CD161和/或IL-18Rα的活的推定的长寿命抗原特异性记忆CD8 + T细胞亚群（CMhi和EMhi）的方法以及快速的能力 流出荧光染料Rh123。
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3.发明授权公开(公告)号：US09931384B2
公开(公告)日：2018-04-03
申请号：US14810286
申请日：2015-07-27
IPC分类号： A61K39/00 , C12N5/0783 , G01N33/50
CPC分类号： A61K39/00 , A61K35/17 , A61K2039/515 , A61K2039/57 , A61K2039/572 , C12N5/0636 , C12N5/0638 , C12N2501/599 , G01N33/505 , G01N2333/54 , G01N2333/70557
摘要： This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory CD8+ T cell subsets (CMhi and EMhi) with high surface expression of CD161 and/or IL-18Rα and the capacity to rapidly efflux the fluorescent dye Rh123.
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公开(公告)号：US20230158164A1
公开(公告)日：2023-05-25
申请号：US17601611
申请日：2020-04-04
发明人： Antonio Mario Querido Marcondes , Peter Benedict Kirk , Takahiro Miyazaki , Cameron J. Turtle , Stanley R. Riddell , Cassie K. Chou , Simon P. Fräßle
CPC分类号： A61K47/642 , A61K35/17 , C07K16/2803 , A61P35/00 , A61K9/0019 , A61K38/1774 , C07K2317/24
摘要： Provided are methods and compositions directed to the treatment of an individual having cancer by (i) administering to the individual an adoptive cellular immunotherapy composition comprising CAR T cells and (ii) administering to the individual an interleukin-15 receptor agonist, such as, for example, a long-acting interleukin-15 receptor agonist.
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公开(公告)号：US10653756B2
公开(公告)日：2020-05-19
申请号：US15903214
申请日：2018-02-23
IPC分类号： C12N5/0783 , A61K39/00 , G01N33/50 , A61K35/17
摘要： This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory CD8+ T cell subsets (CMhi and EMhi) with high surface expression of CD161 and/or IL-18Rα and the capacity to rapidly efflux the fluorescent dye Rh123.
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