Invention Grant
- Patent Title: Antidiabetic bicyclic compounds
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Application No.: US15328908Application Date: 2015-08-03
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Publication No.: US10662171B2Publication Date: 2020-05-26
- Inventor: Harry Chobanian , Duane DeMong , Yan Guo , Barbara Pio , Christopher W. Plummer
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- International Application: PCT/US2015/043360 WO 20150803
- International Announcement: WO2016/022448 WO 20160211
- Main IPC: C07D335/06
- IPC: C07D335/06 ; C07D213/64 ; C07D311/04 ; A61K45/06 ; A61K31/453 ; A61K31/44 ; A61K31/353 ; A61K31/192 ; A61K31/352 ; C07D311/20 ; A61K31/366 ; A61K31/382 ; C07D405/04 ; A61K31/444 ; C07D405/10

Abstract:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Public/Granted literature
- US20170217920A1 ANTIDIABETIC BICYCLIC COMPOUNDS Public/Granted day:2017-08-03
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