An instrument driving mechanism includes an instrument drive assembly (140) including a first set of wheels (136) coupled to a first end portion and a second set (138) of wheels coupled to a second end portion opposite the first end portion. The first set of wheels is configured to engage an elongated instrument (104) therein such that a rotation plane of the first set of wheels is coplanar with a longitudinal axis of the instrument. The second set of wheels is configured to engage the elongated instrument therein such that a rotation plane of the second set of wheels is obliquely oriented with the longitudinal axis of the instrument wherein motion of the instrument is controlled by controlling rotations of the wheels. The instrument drive assembly mounts to a mounting position (149) of a medical device that permits the instrument to pass therethrough and is configured to fix a position of the instrument drive assembly to enable positioning of the instrument.