- 专利标题: Compounds for targeting drug delivery and enhancing siRNA activity
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申请号: US15985614申请日: 2018-05-21
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公开(公告)号: US10669229B2公开(公告)日: 2020-06-02
- 发明人: Yoshiro Niitsu , Joseph E. Payne , John A. Gaudette , Zheng Hou , Victor Knopov , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Violetta Akopian
- 申请人: Nitto Denko Corporation
- 申请人地址: JP Osaka
- 专利权人: Nitto Denko Corporation
- 当前专利权人: Nitto Denko Corporation
- 当前专利权人地址: JP Osaka
- 代理机构: BakerHostetler
- 主分类号: C07C237/22
- IPC分类号: C07C237/22 ; C07C233/21 ; A61K31/07 ; C07F9/10 ; A61K9/127 ; A61K31/713 ; C12N15/113 ; C07C235/08 ; C07C235/48 ; A61K47/55
摘要:
Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.
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