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公开(公告)号：US11103583B2
公开(公告)日：2021-08-31
申请号：US16460812
申请日：2019-07-02
发明人： Joseph E. Payne , John A. Gaudette , Zheng Hou , Mohammad Ahmadian , Lei Yu , Victor Knopov , Violetta Akopian , Priya Karmali , Richard P. Witte , Neda Safarzadeh , Wenbin Ying , Jun Zhang
IPC分类号： A61K47/20 , C07C323/60 , C07D333/38 , C07C271/16 , C07D333/40 , C07C317/44 , C07C333/04 , C07C235/08 , C07C237/08 , C07D207/16 , A61K47/14 , A61K9/127 , A61K47/18 , A61K47/22 , C07C237/16
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
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公开(公告)号：US10441659B2
公开(公告)日：2019-10-15
申请号：US14872951
申请日：2015-10-01
发明人： Joseph E. Payne , John A. Gaudette , Zheng Hou , Mohammad Ahmadian , Lei Yu , Victor Knopov , Violetta Akopian , Priya Karmali , Richard P. Witte , Neda Safarzadeh , Wenbin Ying , Jun Zhang
IPC分类号： A61K47/14 , A61K47/20 , A61K47/18 , A61K47/22 , C07C271/16 , C07D333/40 , C07C317/44 , C07C333/04 , C07C235/08 , C07C237/08 , C07D207/16 , A61K9/127 , C07D333/38 , C07C323/60 , C07C237/16
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
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公开(公告)号：US20170081663A1
公开(公告)日：2017-03-23
申请号：US15284494
申请日：2016-10-03
发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu , Zheng Hou , John A. Gaudette , Priya Karmali , Sridhar C. Nagarajan
IPC分类号： C12N15/113 , A61K47/18 , A61K47/24 , A61K31/713
CPC分类号： C12N15/113 , A61K9/0048 , A61K9/127 , A61K9/1271 , A61K31/713 , A61K45/06 , A61K47/18 , A61K47/186 , A61K47/24 , C07H21/02 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2320/32
摘要： What is described is a pharmaceutical composition for treating a fibrotic disease comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.
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公开(公告)号：US10961181B2
公开(公告)日：2021-03-30
申请号：US16700304
申请日：2019-12-02
发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Zheng Hou , John A. Gaudette , Violetta Akopian , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Priya Karmali , Sridhar C. Nagarajan
IPC分类号： A61K31/713 , C07C237/08 , A61K47/54 , A61K9/00 , A61K9/10 , A61K9/127 , A61K47/18 , C12N15/113 , C07C323/60 , C07C333/04
摘要： Here described is a composition comprising a compound of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl group; R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; X is selected from a group consisting of —CH2—, —S—, and —O— or absent; Y is selected from —(CH2)n, —S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester; n=1-4; a=1-4; b=1-4; c=1-4; and Z− is a counterion.
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公开(公告)号：US20180297938A1
公开(公告)日：2018-10-18
申请号：US15985614
申请日：2018-05-21
发明人： Yoshiro Niitsu , Joseph E. Payne , John A. Gaudette , Zheng Hou , Victor Knopov , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Violetta Akopian
IPC分类号： C07C237/22 , C07C235/48 , A61K47/55 , A61K9/127 , A61K31/713 , C07C233/21 , C07C235/08 , C12N15/113 , C07F9/10 , A61K31/07
摘要： Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.
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公开(公告)号：US20160137593A1
公开(公告)日：2016-05-19
申请号：US15005569
申请日：2016-01-25
发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Zheng Hou , John A. Gaudette , Violetta Akopian , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Priya Karmali , Sridhar C. Nagarajan
IPC分类号： C07C237/08 , C07C333/04 , A61K47/48 , C07C323/60
CPC分类号： C07C237/08 , A61K9/0019 , A61K9/10 , A61K9/1271 , A61K31/713 , A61K47/186 , A61K47/543 , C07C323/60 , C07C333/04 , C12N15/113
摘要： Here described are compounds of formula I: wherein R1 and R2 are independently selected from C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl; R3 and R4 are independently selected from C1 to C6 alkyl and C2 to C6 alkanol; X is selected from —CH2—, —S—, and —O—, or X is absent; Y is selected from —(CH2)n, —S(CH2)n—, —O(CH2)n—, -thiophene-, —SO2(CH2)n—, and ester; n=1-4; a=1-4; b=1-4; c=1-4; and Z− is a counterion. Also described herein are compositions and pharmaceutical formulations including compounds of formula I which are useful for the delivery of therapeutic agents, and methods of using these compositions and formulations.
摘要翻译： 这里描述的是式I化合物：其中R 1和R 2独立地选自C 10至C 18烷基，C 12至C 18烯基和油酰基; R 3和R 4独立地选自C 1至C 6烷基和C 2至C 6烷醇; X选自-CH 2 - ， - S - 和-O-，或X不存在; Y选自 - （CH 2）n，-S（CH 2）n - ， - O（CH 2）n - ， - 噻吩 - ， - SO 2（CH 2）n - n = 1-4; a = 1-4; b = 1-4; c = 1-4; 而Z-是反抗。 本文还描述了可用于递送治疗剂的组合物和药物制剂，包括式I化合物，以及使用这些组合物和制剂的方法。
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公开(公告)号：US11084779B2
公开(公告)日：2021-08-10
申请号：US16700304
申请日：2019-12-02
发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Zheng Hou , John A. Gaudette , Violetta Akopian , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Priya Karmali , Sridhar C. Nagarajan
IPC分类号： A61K31/713 , C07C237/08 , A61K47/54 , A61K9/00 , A61K9/10 , A61K9/127 , A61K47/18 , C12N15/113 , C07C323/60 , C07C333/04
摘要： Here described is a composition comprising a compound of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl group; R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; X is selected from a group consisting of —CH2—, —S—, and —O— or absent; Y is selected from —(CH2)n, —S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester; n=1-4; a=1-4; b=1-4; c=1-4; and Z− is a counterion.
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公开(公告)号：US10669229B2
公开(公告)日：2020-06-02
申请号：US15985614
申请日：2018-05-21
发明人： Yoshiro Niitsu , Joseph E. Payne , John A. Gaudette , Zheng Hou , Victor Knopov , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Violetta Akopian
IPC分类号： C07C237/22 , C07C233/21 , A61K31/07 , C07F9/10 , A61K9/127 , A61K31/713 , C12N15/113 , C07C235/08 , C07C235/48 , A61K47/55
摘要： Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.
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公开(公告)号：US10100004B2
公开(公告)日：2018-10-16
申请号：US15177284
申请日：2016-06-08
发明人： Yoshiro Niitsu , Joseph E. Payne , John A. Gaudette , Zheng Hou , Victor Knopov , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Violetta Akopian
IPC分类号： A61K31/07 , A61K9/127 , C07C237/22 , C07F9/10 , A61K31/713 , C12N15/113 , C07C233/21 , C07C235/08 , C07C235/48 , A61K47/55
摘要： Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.
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公开(公告)号：US09308267B2
公开(公告)日：2016-04-12
申请号：US13913918
申请日：2013-06-10
发明人： Joseph E. Payne , John A. Gaudette , Zheng Hou , Mohammad Ahmadian , Lei Yu , Victor Knopov , Violetta Akopian , Priya Karmali , Richard P. Witte , Neda Safarzadeh , Wenbin Ying , Jun Zhang
IPC分类号： A61K47/18 , A61K47/20 , A61K47/22 , C07C271/16 , C07D333/40 , C07C317/44 , C07C333/04 , C07C235/08 , C07C237/08 , C07D207/16 , A61K47/14 , A61K9/127 , C07D333/38 , C07C323/60
CPC分类号： A61K47/20 , A61K9/1272 , A61K47/14 , A61K47/18 , A61K47/22 , C07C235/08 , C07C237/08 , C07C237/16 , C07C271/16 , C07C317/44 , C07C323/60 , C07C333/04 , C07D207/16 , C07D333/38 , C07D333/40 , Y10T428/2998
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
摘要翻译： 该描述针对可用于增强脂质体中治疗剂递送的可离子化脂质。
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