Invention Grant
- Patent Title: Derivation of hepatic stem cells and mature liver cell types and uses thereof
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Application No.: US15735321Application Date: 2016-06-10
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Publication No.: US10683484B2Publication Date: 2020-06-16
- Inventor: Yuanyu Hu , Huck Hui Ng , Yock Young Dan
- Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE
- Applicant Address: SG Singapore SG Singapore
- Assignee: NATIONAL UNIVERSITY OF SINGAPORE,AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Current Assignee: NATIONAL UNIVERSITY OF SINGAPORE,AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Current Assignee Address: SG Singapore SG Singapore
- Agency: Kilpatrick Townsend & Stockton LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@9464a35 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@94e3d75
- International Application: PCT/SG2016/050270 WO 20160610
- International Announcement: WO2016/200340 WO 20161215
- Main IPC: C12N5/071
- IPC: C12N5/071 ; A61K35/407 ; C12N5/00 ; A61P1/16
Abstract:
This application describes liver stem cells (LSC), and differentiated hepatocytes, cholangiocytes, and 3D cellular structures derived therefrom. Methods for producing LSC and mature, differentiated hepatocytes and cholangiocytes in culture are provided. Also provided are cell culture systems and cell culture media for producing a homogenous population of liver stem cells that remain in an undifferentiated state over multiple passages in culture. The LSC and methods are useful for producing homogenous populations of hepatocytes and cholangiocytes for downstream applications. The LSC can be transplanted into subjects to treat liver diseases.
Public/Granted literature
- US20190161734A1 DERIVATION OF HEPATIC STEM CELLS AND MATURE LIVER CELL TYPES AND USES THEREOF Public/Granted day:2019-05-30
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