- 专利标题: Vaccines against carbapenem-resistant Klebsiella pneumoniae
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申请号: US15560719申请日: 2016-03-29
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公开(公告)号: US10688169B2公开(公告)日: 2020-06-23
- 发明人: Peter H. Seeberger , Claney Lebev Pereira , Guozhi Xiao , Naeem Khan , Chakkumkal Anish
- 申请人: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- 申请人地址: DE Munich
- 专利权人: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- 当前专利权人: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- 当前专利权人地址: DE Munich
- 代理机构: Knobbe Martens Olson & Bear LLP
- 优先权: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@32a93b0b
- 国际申请: PCT/EP2016/056832 WO 20160329
- 国际公布: WO2016/156338 WO 20161006
- 主分类号: C07H15/04
- IPC分类号: C07H15/04 ; C07H15/08 ; A61K31/702 ; A61K31/7028 ; A61K39/108 ; A61K39/00
摘要:
The present invention relates to synthetic saccharides of general formula (I): V*—[Ux+2—Ux+1—Ux]n—V—O-L-NH2 that are related to carbapenem-resistant Klebsiella pneumoniae capsular polysaccharide and conjugates thereof. Said conjugates and pharmaceutical composition containing said conjugates are useful for prevention and/or treatment of diseases associated with carbapenem-resistant Klebsiella pneumoniae. Furthermore, the synthetic saccharides of general formula (I): V*—[Ux+2—Ux+1—Ux]n—V—O-L-NH2 are useful as marker in immunological assays for detection of antibodies against carbapenem-resistant Klebsiella pneumoniae bacteria.
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