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公开(公告)号：US20220387957A1
公开(公告)日：2022-12-08
申请号：US17773894
申请日：2020-11-04
发明人： Peter H. Seeberger , Jose Danglad Flores , Kim Le Mai Hoang , Alonso Pardo Vargas , Eric Sletten , Mario Salwiczek
IPC分类号： B01J19/00
摘要： The present invention relates to a method for synthesizing oligo- and polysaccharides using microwave radiation, in particular to a method and a device for automated synthesis of oligo- and polysaccharides.
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公开(公告)号：US20220380485A1
公开(公告)日：2022-12-01
申请号：US17766052
申请日：2020-10-02
发明人： Peter H. Seeberger , Oren Moscovitz
摘要： The present invention relates to the field of single-domain antibodies (sdAb) directed towards the glycans of the globo series, and in particular Globo H. More in detail, the present invention relates to sdAbs specifically binding one or more glycans selected from Globo H, Gb3, Gb4, and Gb5. The invention also provides polypeptides comprising multimeric single domain antibodies, as well as T cell chimeric antigen receptors comprising said anti-glycan sdAbs. Thus, the present invention provides polypeptides that can be used for targeting and/or treating several types of cancers associated with cells over-expressing said Globo H and/or Gb3, Gb4, Gb5. The present invention also relates to recombinant nucleic acid sequences encoding said polypeptides, and expression vectors and host cells comprising the same.
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公开(公告)号：US09802952B2
公开(公告)日：2017-10-31
申请号：US14904671
申请日：2014-07-14
IPC分类号： C07D493/18 , B01J19/24
CPC分类号： C07D493/18 , B01J19/245 , B01J2219/24
摘要： The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C1-C5 alcohol.
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公开(公告)号：US20170239341A1
公开(公告)日：2017-08-24
申请号：US15513868
申请日：2015-09-28
发明人： Peter H. Seeberger , Claney Lebev Pereira , Chakkumkal Anish , Benjamin Schumann , Sharavathi Guddehalli Parameswarappa , Heung Sik Hahm , Subramanian Govindan
IPC分类号： A61K39/09 , G01N33/569 , C07H15/04
CPC分类号： A61K39/092 , A61K31/7028 , A61K39/085 , A61K47/6415 , A61K47/646 , A61K2039/575 , A61K2039/6037 , A61K2039/627 , C07H15/04 , C07H15/18 , C07K16/1271 , G01N33/56944 , G01N2333/3156
摘要： The present invention relates to synthetic saccharides of general formula (I) that are related to Streptococcus pneumoniae serotype 8 capsular polysaccharide, conjugates thereof and the use of said saccharides and conjugates for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide structures of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.
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公开(公告)号：US20160346374A1
公开(公告)日：2016-12-01
申请号：US14903118
申请日：2014-07-07
IPC分类号： A61K39/09 , A61K47/48 , G01N33/569 , C07H15/04
CPC分类号： A61K39/092 , A61K31/7028 , A61K47/646 , A61K2039/6037 , A61K2039/627 , C07H15/04 , G01N33/56944 , G01N2333/3156 , G01N2469/20
摘要： The present invention relates to the total synthesis of saccharide structures contained in the capsular polysaccharide of Streptococcus pneumoniae type 1, to glycoconjugates containing said saccharide structures obtained by total synthesis and to use of such glycoconjugates and pharmaceutical compositions thereof in the immunization against diseases associated with bacteria containing said saccharide structures in their capsular polysaccharide, and more specifically associated with Streptococcus pneumoniae.
摘要翻译： 本发明涉及包含在1型肺炎链球菌的荚膜多糖中的糖结构的全合成，含有通过全合成获得的所述糖结构的糖缀合物，以及这些糖缀合物的使用及其药物组合物在与细菌相关的疾病的免疫中 在其荚膜多糖中含有所述糖结构，更具体地与肺炎链球菌有关。
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公开(公告)号：US11191822B2
公开(公告)日：2021-12-07
申请号：US16312189
申请日：2017-06-22
发明人： Peter H. Seeberger , Claney Lebev Pereira , Madhu Emmadi , Sharavathi Guddehalli Parameswarappa , Adam Calow , Petra Menova , Marilda Lisboa , Christopher Martin , Benjamin Schumann , Fei-Fei Xu , Naeem Khan , Paulina Kaplonek , Lennart Lykke
摘要： The present invention relates to immunogenic compositions comprising a conjugate of a saccharide from Streptococcus pneumoniae serotype 8 and a carrier protein, and a mixture consisting of capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F individually conjugated to CRM197 carrier protein, or a mixture consisting of capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F individually conjugated to a carrier protein, wherein the capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, and 23F are individually conjugated to protein D, the capsular polysaccharide from Streptococcus pneumoniae serotype 18C is conjugated to tetanus toxoid and the capsular polysaccharide from Streptococcus pneumoniae serotype 19F is conjugated to diphtheria toxoid. Said compositions are useful for the prevention and/or treatment of diseases caused by Streptococcus pneumoniae.
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公开(公告)号：US20200016257A1
公开(公告)日：2020-01-16
申请号：US16061478
申请日：2016-12-16
摘要： The present invention relates to a synthetic saccharide of general formula (I) that is related to Streptococcus pneumoniae serotype 2 capsular polysaccharide, a conjugate thereof and the use of said saccharide and conjugate for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae type 2 bacteria.
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公开(公告)号：US10220083B2
公开(公告)日：2019-03-05
申请号：US15513868
申请日：2015-09-28
发明人： Peter H. Seeberger , Claney Lebev Pereira , Chakkumkal Anish , Benjamin Schumann , Sharavathi Guddehalli Parameswarappa , Heung Sik Hahm , Subramanian Govindan
IPC分类号： A61K31/7028 , A61K39/09 , C07H15/18 , C07H15/04 , A61K39/085 , C07K16/12 , G01N33/569 , A61K47/64 , A61K39/00
摘要： The present invention relates to synthetic saccharides of general formula (I) that are related to Streptococcus pneumoniae serotype 8 capsular polysaccharide, conjugates thereof and the use of said saccharides and conjugates for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide structures of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.
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公开(公告)号：US10188718B2
公开(公告)日：2019-01-29
申请号：US15534676
申请日：2015-05-15
IPC分类号： A61K31/7028 , A61K39/09 , A61K31/715 , C08B37/00 , C07H15/02 , C07H15/04 , A61K39/385 , C07H15/18 , G01N33/569 , A61K39/00
摘要： The present invention relates to synthetic saccharides of general formula (I) that are related to Streptococcus pneumoniae serotype 4 capsular polysaccharide and conjugates thereof. Said conjugate and a pharmaceutical composition containing said conjugate are useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically of diseases associated with Streptococcus pneumoniae serotype 4. Furthermore, the synthetic saccharides of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.
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公开(公告)号：US09409142B2
公开(公告)日：2016-08-09
申请号：US14810882
申请日：2015-07-28
IPC分类号： C07D321/00 , B01J19/12 , C07D493/22 , B01J19/08 , C07D321/10
CPC分类号： B01J19/12 , B01J19/08 , B01J2219/0871 , B01J2219/0892 , C07D321/10 , C07D493/22
摘要： The present invention is directed to a method for producing artemisinin having the formula from dihydroartemisinic acid in a continuous flow reactor using singlet oxygen as well as to the continuous flow reactor for producing artemisinin.
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