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公开(公告)号：US10688169B2
公开(公告)日：2020-06-23
申请号：US15560719
申请日：2016-03-29
IPC分类号： C07H15/04 , C07H15/08 , A61K31/702 , A61K31/7028 , A61K39/108 , A61K39/00
摘要： The present invention relates to synthetic saccharides of general formula (I): V*—[Ux+2—Ux+1—Ux]n—V—O-L-NH2 that are related to carbapenem-resistant Klebsiella pneumoniae capsular polysaccharide and conjugates thereof. Said conjugates and pharmaceutical composition containing said conjugates are useful for prevention and/or treatment of diseases associated with carbapenem-resistant Klebsiella pneumoniae. Furthermore, the synthetic saccharides of general formula (I): V*—[Ux+2—Ux+1—Ux]n—V—O-L-NH2 are useful as marker in immunological assays for detection of antibodies against carbapenem-resistant Klebsiella pneumoniae bacteria.
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公开(公告)号：US11191822B2
公开(公告)日：2021-12-07
申请号：US16312189
申请日：2017-06-22
发明人： Peter H. Seeberger , Claney Lebev Pereira , Madhu Emmadi , Sharavathi Guddehalli Parameswarappa , Adam Calow , Petra Menova , Marilda Lisboa , Christopher Martin , Benjamin Schumann , Fei-Fei Xu , Naeem Khan , Paulina Kaplonek , Lennart Lykke
摘要： The present invention relates to immunogenic compositions comprising a conjugate of a saccharide from Streptococcus pneumoniae serotype 8 and a carrier protein, and a mixture consisting of capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F individually conjugated to CRM197 carrier protein, or a mixture consisting of capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F individually conjugated to a carrier protein, wherein the capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, and 23F are individually conjugated to protein D, the capsular polysaccharide from Streptococcus pneumoniae serotype 18C is conjugated to tetanus toxoid and the capsular polysaccharide from Streptococcus pneumoniae serotype 19F is conjugated to diphtheria toxoid. Said compositions are useful for the prevention and/or treatment of diseases caused by Streptococcus pneumoniae.
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公开(公告)号：US20200016257A1
公开(公告)日：2020-01-16
申请号：US16061478
申请日：2016-12-16
摘要： The present invention relates to a synthetic saccharide of general formula (I) that is related to Streptococcus pneumoniae serotype 2 capsular polysaccharide, a conjugate thereof and the use of said saccharide and conjugate for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae type 2 bacteria.
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公开(公告)号：US20180078630A1
公开(公告)日：2018-03-22
申请号：US15560719
申请日：2016-03-29
IPC分类号： A61K39/108 , C07H15/04
摘要： The present invention relates to synthetic saccharides of general formula (I): V*—[Ux+2—Ux+1—Ux]n—V—O-L-NH2 that are related to carbapenem-resistant Klebsiella pneumoniae capsular polysaccharide and conjugates thereof. Said conjugates and pharmaceutical composition containing said conjugates are useful for prevention and/or treatment of diseases associated with carbapenem-resistant Klebsiella pneumoniae. Furthermore, the synthetic saccharides of general formula (I): V*—[Ux+2—Ux+1—Ux]n—V—O-L-NH2 are useful as marker in immunological assays for detection of antibodies against carbapenem-resistant Klebsiella pneumoniae bacteria.
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公开(公告)号：US10596272B2
公开(公告)日：2020-03-24
申请号：US15580069
申请日：2016-01-26
发明人： Chakkumkal Anish , Marilda Lisboa , Christopher Martin , Claney Lebev Pereira , Peter H. Seeberger , Naeem Khan
IPC分类号： A61K31/702 , A61K31/7016 , A61K39/09 , A61K31/7028 , A61K39/00 , A61K47/64 , C07H15/04 , A61K45/06 , C07H15/06 , A61P31/04
摘要： The present invention relates to well-defined synthetic saccharides of general formula (I) that are related to the repeating unit of Streptococcus pneumoniae serotype 5 capsular polysaccharide and conjugates thereof. The conjugates and pharmaceutical compositions containing said conjugates are useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically against diseases associated with Streptococcus pneumoniae serotype 5. Furthermore, the synthetic saccharides of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.
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公开(公告)号：US20190240309A1
公开(公告)日：2019-08-08
申请号：US16312189
申请日：2017-06-22
发明人： Peter H. Seeberger , Claney Lebev Pereira , Madhu Emmadi , Sharavathi Guddehalli Parameswarappa , Adam Calow , Petra Menova , Marilda Lisboa , Christopher Martin , Benjamin Schumann , Fei-Fei Xu , Naeem Khan , Paulina Kaplonek , Lennart Lykke
CPC分类号： A61K39/092 , A61K2039/55505 , A61K2039/6037 , A61K2039/62 , A61P31/04
摘要： The present invention relates to immunogenic compositions comprising a conjugate of a saccharide from Streptococcus pneumoniae serotype 8 and a carrier protein, and a mixture consisting of capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F individually conjugated to CRM197 carrier protein, or a mixture consisting of capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F individually conjugated to a carrier protein, wherein the capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, and 23F are individually conjugated to protein D, the capsular polysaccharide from Streptococcus pneumoniae serotype 18C is conjugated to tetanus toxoid and the capsular polysaccharide from Streptococcus pneumoniae serotype 19F is conjugated to diphtheria toxoid. Said compositions are useful for the prevention and/or treatment of diseases caused by Streptococcus pneumoniae.
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