- Patent Title: Modified polynucleotides for the production of secreted proteins
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Application No.: US16438978Application Date: 2019-06-12
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Publication No.: US10703789B2Publication Date: 2020-07-07
- Inventor: Antonin De Fougerolles , Justin Guild
- Applicant: ModernaTX, Inc.
- Applicant Address: US MA Cambridge
- Assignee: ModernaTX, Inc.
- Current Assignee: ModernaTX, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Clark & Elbing LLP
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K38/17 ; A61K47/54 ; A61K9/127 ; C07K14/535 ; C12N15/88 ; A61K9/50 ; C07K14/47 ; A61K31/7088 ; C07K19/00 ; C12N15/85 ; A61K38/18 ; A61K38/19 ; A61K38/48 ; A61K9/14 ; A61K47/10 ; A61K38/21 ; A61K38/36 ; A61K38/44 ; A61K39/395 ; C07K14/475 ; C07K14/505 ; C07K14/525 ; C07K14/56 ; C07K14/565 ; C07K14/745 ; C07K14/75 ; C07K16/28 ; C07K16/32 ; C12N9/02 ; C12N9/64 ; A61K31/7115 ; C07K14/005 ; C12N15/11 ; C12N9/00 ; A61K9/00
Abstract:
A pharmaceutical composition which has a plurality of lipid nanoparticles that has a mean particle size of between 80 nm and 160 nm and contains a modified mRNA encoding a polypeptide. The lipid nanoparticles include a cationic lipid, a neutral lipid, a cholesterol, and a PEG lipid. The mRNA contains a 5′-cap, 5′-UTR, N1-methyl-pseudouridine, a 3′-UTR, and a poly-A region with at least 100 nucleotides.
Public/Granted literature
- US20200017565A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS Public/Granted day:2020-01-16
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