A novel hot-melt adhesive and a preparation method thereof are disclosed, and in particular a hot-melt adhesive for bonding aluminum, stainless steel or other metal materials and PVC plastics is disclosed. The specific nylon-type copolyamide is firstly prepared by designing specific raw materials and percentage thereof, and in combination with favorable bonding properties of the nylon-type copolyamide for metals and favorable bonding characteristics of the perchloroethylene resin for PVC, a double screw extruder is utilized to perform sufficient melt blending on the nylon-type copolyamide and the perchloroethylene resin under the synergistic actions of related aids, so that the obtained novel hot-melt adhesive has favorable bonding properties for both metals and PVC.