Exemplary methods, apparatuses, and systems include a distributed memory agent within a first node intercepting an operating system request to open a file from an application running on the first node. The request includes a file identifier, which the distributed memory agent transmits to a remote memory manager. The distributed memory agent receives, from the remote memory manager, a memory location within a second node for the file identifier and information to establish a remote direct memory access channel between the first node and the second node. In response to the request to open the file, the distributed memory agent establishes the remote direct memory access channel between the first node and the second node. The remote direct memory access channel allows the first node to read directly from or write directly to the memory location within the second node while bypassing an operating system of the second node.