- 专利标题: Inhibitors of β-hydroxylase for treatment of cancer
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申请号: US15715989申请日: 2017-09-26
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公开(公告)号: US10710995B2公开(公告)日: 2020-07-14
- 发明人: Jack R. Wands , Suzanne De La Monte , Arihiro Aihara , Mark Jon Olsen , John-Michael Thomas
- 申请人: Rhode Island Hospital , Midwestern University
- 申请人地址: US RI Providence US IL Downers Grove
- 专利权人: Rhode Island Hospital,Midwestern University
- 当前专利权人: Rhode Island Hospital,Midwestern University
- 当前专利权人地址: US RI Providence US IL Downers Grove
- 代理机构: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- 代理商 Ingrid A. Beattie; Joohee Lee
- 主分类号: A61K31/34
- IPC分类号: A61K31/34 ; A61K31/16 ; C07D417/04 ; C07D307/66 ; A61P35/00 ; C07D307/32 ; C07D405/04 ; C07D405/12 ; C07D409/04 ; C12Q1/26
摘要:
The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.
公开/授权文献
- US20180237427A1 INHIBITORS OF BETA-HYDROXYLASE FOR TREATMENT OF CANCER 公开/授权日:2018-08-23