- 专利标题： HIV immune stimulating compositions comprising recombinantly expressed pili on bacteria and methods related thereto
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申请号： US15848706申请日： 2017-12-20
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公开(公告)号： US10729762B2公开(公告)日： 2020-08-04
- 发明人: Rama Rao Amara , June Scott , Bernard Quigley , Venkateswarlu Chamcha
- 申请人： Emory University
- 申请人地址： US GA Atlanta
- 专利权人： Emory University
- 当前专利权人： Emory University
- 当前专利权人地址： US GA Atlanta
- 代理机构： Emory Patent Group
- 主分类号： A61K39/21
- IPC分类号： A61K39/21 ; C07K14/005 ; A61K39/12 ; A61K45/06 ; C12N7/00 ; A61K39/00
摘要：
This disclosure relates to recombinant bacteria, e.g. L. lactis, expressing heterologous pili containing human immunodeficiency virus (HIV) antigens. In certain embodiments, the recombinant bacteria are administered in combination with other HIV antigens, nucleic acids encoding HIV antigens, recombinant virus encoding HIV antigens, anti-viral agents and/or adjuvants in an effective amount to elicit a mucosal immune response against HIV.
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