A protective bottle enclosure includes a base portion defined by a base sidewall secured to a base bottom wall and has a base opening disposed opposite the base bottom wall. An upper portion has upper sidewalls surrounding an internal cavity. The upper portion has a cylindrical body section and the neck section is narrower than the lower section. The lower section ends in a lower opening and a lower thread. The neck section narrows in diameter between the body section and a neck opening and has a neck thread. The lower section can be inserted into the base opening and can threadably engage the base side wall. A removable cap can threadably engage the neck section and includes an elastomeric stopper connected to a cylindrical sleeve. The combination of the removable cap, the upper portion, and the base portion can surround and enclose the bottle.