Doherty power amplifier having high supply voltage. In some embodiments, a power amplification system can include a supply system configured to provide a high-voltage supply signal, and a Doherty power amplifier having an input splitter configured to receive and split a signal into a carrier amplifier and a peaking amplifier. The Doherty power amplifier can further include a combiner configured to combine amplified signals from the carrier and peaking amplifiers to provide an output signal. The Doherty power amplifier can be configured to receive the high-voltage supply signal for operation of the carrier and peaking amplifiers. The power amplification system can further include an output path configured to couple the combiner to a filter. The Doherty power amplifier can have an impedance substantially the same as an impedance of the filter when operated with the high-voltage supply signal.