Invention Grant
- Patent Title: Analyzing immune signaling networks for identification of therapeutic targets in complex chronic medical disorders
-
Application No.: US15028757Application Date: 2014-10-14
-
Publication No.: US10777298B2Publication Date: 2020-09-15
- Inventor: Mary Ann Fletcher , Gordon Broderick , Nancy Klimas , Zachary Barnes
- Applicant: NOVA SOUTHEASTERN UNIVERSITY , UNIVERSITY OF MIAMI , UNIVERSITY OF ALBERTA, TEC EDMONTON
- Applicant Address: US FL Fort Lauderdale US FL Miami US CA Edmonton
- Assignee: Nova Southeastern University,University of Miami,University of Alberta, TEC Edmonton
- Current Assignee: Nova Southeastern University,University of Miami,University of Alberta, TEC Edmonton
- Current Assignee Address: US FL Fort Lauderdale US FL Miami US CA Edmonton
- Agency: Fleit Intellectual Property Law
- Agent Paul D. Bianco; Katherine Wong Davis
- International Application: PCT/US2014/060535 WO 20141014
- International Announcement: WO2015/054701 WO 20150416
- Main IPC: G16B5/00
- IPC: G16B5/00 ; G16B40/00 ; A61K38/20
Abstract:
A general method of analyzing immune signaling networks for identification of potential therapeutic targets in complex, chronic medical disorders is described. The disclosure provides the CD3−/CD56+ natural killer (NK) cell population as a potential therapeutic target in the clinically-overlapping disorders Gulf War Illness (GWI) and Myalg Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The disclosure also provides a method for improving or restoring Natural Killer (NK) cell function by stimulating the NK cells with interleukin-15 (IL-15).
Public/Granted literature
Information query
