公开(公告)号：US20240002438A1

公开(公告)日：2024-01-04

申请号：US17944574

申请日：2022-09-14

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  FLORIDA INTERNATIONAL UNIVERSITY ,  NOVA SOUTHEASTERN UNIVERSITY

Inventor： Carrie Haskell-Luevano ,  Mark David Ericson ,  Richard A. Houghten ,  Clemencia Pinilla ,  Marcello Angelo Giulianotti ,  Radleigh G. Santos

IPC: C07K5/117 ,  C07K5/107

CPC classification number: C07K5/1024 ,  C07K5/1016 ,  A61K38/00

Abstract: Certain embodiments of the invention provide a compound of formula (I) or a compound of formula (II):


R1—A1—A2—A3—A4—N(R2)2   (I)



R3—A5—A6—A7—A8—N(R4)2   (II)

or a salt thereof, wherein R1, R2, R3, R4, A1, A2, A3, A4, A5, A6, A7, and A8 are as defined herein, as well as methods of use thereof.

公开(公告)号：US20220409581A1

公开(公告)日：2022-12-29

申请号：US17776273

申请日：2020-11-13

Applicant: Nova Southeastern University

Inventor： Appu RATHINAVELU ,  Thiagarajan VENKATESAN ,  Jayanta K. DAS ,  Mohammad Mansour S. ALGAHTANI

IPC: A61K31/4035 ,  A61K31/495 ,  A61K39/395 ,  A61P35/00

Abstract: The invention provides methods for using F16 isoindole small molecules for treatment of solid tumors, particularly brain cancers, such as glioblastoma multiforme (GBM). F16 isoindole is an inhibitor of angiogenesis and is capable of antagonizing tumor vasculature. The invention also provides pharmaceutical compositions including F16 isoindole small molecules.

公开(公告)号：US10777298B2

公开(公告)日：2020-09-15

申请号：US15028757

申请日：2014-10-14

Applicant: NOVA SOUTHEASTERN UNIVERSITY ,  UNIVERSITY OF MIAMI ,  UNIVERSITY OF ALBERTA, TEC EDMONTON

Inventor： Mary Ann Fletcher ,  Gordon Broderick ,  Nancy Klimas ,  Zachary Barnes

IPC: G16B5/00 ,  G16B40/00 ,  A61K38/20

Abstract: A general method of analyzing immune signaling networks for identification of potential therapeutic targets in complex, chronic medical disorders is described. The disclosure provides the CD3−/CD56+ natural killer (NK) cell population as a potential therapeutic target in the clinically-overlapping disorders Gulf War Illness (GWI) and Myalg Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The disclosure also provides a method for improving or restoring Natural Killer (NK) cell function by stimulating the NK cells with interleukin-15 (IL-15).

公开(公告)号：US20200176086A1

公开(公告)日：2020-06-04

申请号：US16624320

申请日：2018-06-29

Applicant: Nova Southeastern University

Inventor： Nancy KLIMAS ,  Kelly HILTON ,  Kristina GEMAYEL

IPC: G16B50/30 ,  G16H20/10 ,  G16B20/20 ,  G16H10/20

Abstract: The invention provides a method for compiling a genomic database for a complex disease, such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and a method for using the database for identifying genetic patterns that can potentially categorize, diagnose, and/or predict therapeutics for the complex disease.

公开(公告)号：US20190090731A1

公开(公告)日：2019-03-28

申请号：US16087194

申请日：2017-03-23

Applicant: NOVA SOUTHEASTERN UNIVERSITY

Inventor： Daniel J. Young

IPC: A61B1/253 ,  A61B1/00 ,  A61B1/015

Abstract: A cleaning tool is attachable to a dental air-water syringe tip. The tool has a frame which supports a mirrored surface. tool grip is attached to the frame, and includes a resilient body and a channel extending through the body. The channel is sized smaller than a diameter of the syringe tip. A support arm connects the frame and the tool grip, and the frame and the tool grip are each connected to the support arm at a predetermined angle which causes there to be a predetermined angle between a longitudinal axis of the channel, and thus the output of the tool tip, and the mirror surface.

公开(公告)号：US12224068B2

公开(公告)日：2025-02-11

申请号：US16961266

申请日：2019-01-11

Applicant: Nova Southeastern University ,  Emory University

Inventor： Raymond L. Ownby ,  Amarilis Acevedo ,  Drenna Waldrop-Valverde

IPC: G16H50/30 ,  G16H10/20 ,  G16H10/60

Abstract: An electronic processing system agent accesses population health literacy data from at least 100 individuals pertaining to assessed health literacy of members of the population, and demographic data from the population corresponding to age, race, and education level. The agent collects skills data from the patient corresponding to a set of questions relating to skills needed for understanding therapeutic instructions, and personal data relating to the patient's age, race, and education level. The agent carries out a polytomous logistic regression using the collected population health literacy data, demographic data, skills data, and personal data to assign a health literacy level to the patient corresponding to one of a plurality of groups, and communicates a strategy for the patient corresponding to the patient's assigned health literacy level, in real time, to enable the patient to have a communication of therapeutic instructions when the patient has responded to the set of questions.

公开(公告)号：US20240280720A1

公开(公告)日：2024-08-22

申请号：US18569108

申请日：2022-06-27

Applicant: NOVA SOUTHEASTERN UNIVERSITY, INC.

Inventor： Alexander V. SOLOVIEV ,  Cayla W. DEAN

IPC: G01V3/08 ,  G01C13/00 ,  G01R33/02 ,  G01V3/38

CPC classification number: G01V3/081 ,  G01V3/38 ,  G01C13/002 ,  G01R33/02

Abstract: Systems and methods to detect ferromagnetic objects, particularly submerged, non-naturally occurring ferromagnetic objects, account for contributions to the magnetic field arising from topography, such as magnetic refraction at bathymetric slopes. Removing this topography component of noise from detected total magnetic field enhances detection capability of, for example, naval surveillance systems.

公开(公告)号：US20220215494A1

公开(公告)日：2022-07-07

申请号：US17702906

申请日：2022-03-24

Applicant: NOVA SOUTHEASTERN UNIVERSITY

Inventor： Farzanna S. Haffizulla ,  Anjali Ramoutar ,  Vejendra Ammar ,  Hemangi Rajpal ,  Anam Ahmed

IPC: G06Q50/20 ,  G09B5/14 ,  H04L67/50

Abstract: A computer-based system, and a computer-implemented method, mentors students, particularly women and ethnic and racial minorities, intending to enter healthcare professions. The system uses a gamified mobile-enabled web application (App) that serves as a visual and interactive dashboard populated with checklists, career support resources, strategies, tips, and a mentoring platform to educate, encourage, empower, and facilitate the entry of students into the healthcare professions.

公开(公告)号：US10682316B2

公开(公告)日：2020-06-16

申请号：US15358743

申请日：2016-11-22

Applicant: NOVA SOUTHEASTERN UNIVERSITY

Inventor： Mutasem Rawas-Qalaji ,  Ousama Rachid ,  Keith John Simons ,  Estelle Simons ,  Enrique Nieves

IPC: A61K31/137 ,  A61K9/19 ,  A61K9/00 ,  A61K9/14

Abstract: The invention provides a composition including epinephrine nanoparticles and methods for therapeutic use of the composition in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

公开(公告)号：US10397622B2

公开(公告)日：2019-08-27

申请号：US16119403

申请日：2018-08-31

Applicant: NOVA SOUTHEASTERN UNIVERSITY

Inventor： Abdelkrim Bourouihiya

IPC: H04N21/2347 ,  H04N19/46 ,  G06F17/16 ,  H04L9/30

Abstract: Digital files are compressed using a process including Schmidt decompositions of matrices using an algorithm, termed ‘BSD’ herein, which is based on an algebraic method generalizing QR decomposition. Software analyzes an input file and initially identifies a matrix M, with entries within a predefined set of integers, within the file. Next, essential entries are defined, extracted from M, that contain sufficient information to recover M using BSD. The compressed file includes the essential entries and their positions within M. To achieve an encryption process, software encrypts the pattern matrix that includes the positions of the essential entries of M. To achieve a lossy compression, software identifies essential entries that contain sufficient information to recover an approximation to M for which the quality is determined by an error threshold. For a more efficient lossy compression, software uses singular value decomposition, BSD, and other signal processing of M.