Provided are an operation method in accordance with uplink semi-persistent scheduling (SPS) of a terminal in a wireless communication system and a terminal using the method. The method is characterized by: receiving, from a base station, downlink control information (DCI) for indicating activation or release of uplink SPS; and decoding the DCI on the basis of a first radio network temporary identifier (RNTI) or a second RNTI. If the DCI is a first DCI for SPS for transmitting a signal to the base station, the DCI is decoded on the basis of the first RNTI, and, if the DCI is a second DCI for SPS for transmitting a vehicle-to-everything (V2X) signal, the DCI is decoded on the basis of the second RNTI. And the first RNTI and second RNTI are RNTIs that are different from each other.