- 专利标题: Inhibitors of beta-hydroxylase for treatment of cancer
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申请号: US16439253申请日: 2019-06-12
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公开(公告)号: US10787445B2公开(公告)日: 2020-09-29
- 发明人: Mark Jon Olsen , John-Michael Thomas
- 申请人: Midwestern University
- 申请人地址: US IL Downers Grove
- 专利权人: Midwestern University
- 当前专利权人: Midwestern University
- 当前专利权人地址: US IL Downers Grove
- 代理机构: Reed Smith LLP
- 代理商 Matthew S. Gibson
- 主分类号: C07D307/26
- IPC分类号: C07D307/26 ; C07D405/04 ; C07D417/04 ; C07D409/04 ; C07D405/12 ; C07D307/32 ; C07D307/66 ; A61P35/00 ; C12Q1/26
摘要:
The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.
公开/授权文献
- US20190300519A1 Inhibitors of Beta-Hydroxylase for Treatment of Cancer 公开/授权日:2019-10-03