Invention Grant
- Patent Title: Methods and compositions for improving efficiency of nucleic acids amplification reactions
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Application No.: US15977254Application Date: 2018-05-11
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Publication No.: US10787694B2Publication Date: 2020-09-29
- Inventor: Xiao-Song Gong , John Sullivan , Rongdian Fu , Yan Wang , Evan H. Bursey , Man Cheng
- Applicant: Bio-Rad Laboratories, Inc.
- Applicant Address: US CA Hercules
- Assignee: Bio-Rad Laboratories, Inc.
- Current Assignee: Bio-Rad Laboratories, Inc.
- Current Assignee Address: US CA Hercules
- Agency: Kilpatrick Townsend and Stockton LLP
- Main IPC: C07K19/00
- IPC: C07K19/00 ; C12Q1/6804 ; C12Q1/686 ; C12P19/34 ; C07K16/40 ; C12N9/12
Abstract:
The present invention provides methods and compositions for improving the efficiency of nucleic acid amplification reactions. The invention encompasses hybrid polymerases that show increased processivity over wild type polymerases as well as decreased exonucleases activity. The invention also encompasses methods, compositions and kits for conducting nucleic acid synthesis and amplification reactions in which non-specific amplification of primers is reduced.
Public/Granted literature
- US20180258455A1 METHODS AND COMPOSITIONS FOR IMPROVING EFFICIENCY OF NUCLEIC ACIDS AMPLIFICATION REACTIONS Public/Granted day:2018-09-13
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