- 专利标题: Antibody/T-cell receptor chimeric constructs and uses thereof
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申请号: US16667781申请日: 2019-10-29
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公开(公告)号: US10822389B2公开(公告)日: 2020-11-03
- 发明人: Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
- 申请人: EUREKA THERAPEUTICS, INC.
- 申请人地址: US CA Emeryville
- 专利权人: EUREKA THERAPEUTICS, INC.
- 当前专利权人: EUREKA THERAPEUTICS, INC.
- 当前专利权人地址: US CA Emeryville
- 代理机构: Morrison & Foerster LLP
- 主分类号: A61P35/00
- IPC分类号: A61P35/00 ; C07K14/725 ; A61K35/17 ; C12N15/62 ; A61K38/00 ; A61K39/395 ; C07K16/28 ; A61K39/00
摘要:
The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
公开/授权文献
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IPC分类:
A | 人类生活必需 |
A61 | 医学或兽医学;卫生学 |
A61P | 化合物或药物制剂的特定治疗活性 |
A61P35/00 | 抗肿瘤药 |