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公开(公告)号：US11976105B2
公开(公告)日：2024-05-07
申请号：US17181913
申请日：2021-02-22
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： C07K14/725 , A61K35/17 , A61K38/00 , A61K39/00 , A61K39/395 , A61P35/00 , C07K16/28 , C12N15/62
CPC分类号： C07K14/7051 , A61K35/17 , A61K38/00 , A61K39/39558 , A61P35/00 , C07K16/2809 , C07K16/2833 , C12N15/62 , A61K2039/505 , C07K16/2803 , C07K2317/51 , C07K2317/515 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/33 , C07K2319/74
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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公开(公告)号：US10464988B2
公开(公告)日：2019-11-05
申请号：US16121475
申请日：2018-09-04
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： A61K35/17 , C07K14/725 , C12N15/62 , A61K38/00 , A61K39/395 , C07K16/28 , A61K39/00
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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公开(公告)号：US11981742B2
公开(公告)日：2024-05-14
申请号：US16388508
申请日：2019-04-18
发明人： Hong Liu , Jingwei Lu , Zhiyuan Yang , Li Long , Neal Cheng
IPC分类号： C07K16/28 , A61K35/17 , A61K39/00 , A61P35/00 , C07K14/725 , C07K16/30 , C12N5/0783 , A61K38/00 , C07K14/705
CPC分类号： C07K16/2896 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K16/2803 , C07K16/3061 , C12N5/0638 , A61K38/00 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , C07K14/70521 , C07K16/2809 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/02 , C07K2319/03 , C12N2501/599 , C12N2510/00
摘要： Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by CD 19 expression, in particular, B cell lymphomas and leukemias.
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公开(公告)号：US11421013B2
公开(公告)日：2022-08-23
申请号：US15769724
申请日：2016-10-21
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： C07K14/725 , A61K35/17 , C12N15/62 , A61K38/00 , A61P35/00 , A61K39/395 , C07K16/28 , A61K39/00
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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公开(公告)号：US10822389B2
公开(公告)日：2020-11-03
申请号：US16667781
申请日：2019-10-29
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： A61P35/00 , C07K14/725 , A61K35/17 , C12N15/62 , A61K38/00 , A61K39/395 , C07K16/28 , A61K39/00
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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公开(公告)号：US20180134787A1
公开(公告)日：2018-05-17
申请号：US15840870
申请日：2017-12-13
发明人： HONG LIU , Jingwei Lu , Zhiyuan Yang , Li Long , Neal Cheng
IPC分类号： C07K16/28 , A61K35/17 , C07K14/725 , C07K14/705 , A61P35/00 , C07K16/30
CPC分类号： C07K16/2803 , A61K35/17 , A61K38/00 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , A61P35/00 , C07K14/7051 , C07K14/70521 , C07K16/2809 , C07K16/3061 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/02 , C07K2319/03 , C12N5/0638 , C12N2501/599 , C12N2510/00
摘要： Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by CD 19 expression, in particular, B cell lymphomas and leukemias.
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公开(公告)号：US20190315859A1
公开(公告)日：2019-10-17
申请号：US16388508
申请日：2019-04-18
发明人： HONG LIU , Jingwei Lu , Zhiyuan Yang , Li Long , Neal Cheng
IPC分类号： C07K16/28 , C12N5/0783 , C07K16/30 , C07K14/725 , A61K35/17 , C07K14/705 , A61P35/00
摘要： Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by CD 19 expression, in particular, B cell lymphomas and leukemias.
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公开(公告)号：US10301388B2
公开(公告)日：2019-05-28
申请号：US15840870
申请日：2017-12-13
发明人： Hong Liu , Jingwei Lu , Zhiyuan Yang , Li Long , Neal Cheng
IPC分类号： C07K16/28 , A61K35/17 , C12N5/0783 , A61P35/00 , C07K14/725 , C07K14/705 , C07K16/30 , A61K39/00 , A61K38/00
摘要： Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by CD 19 expression, in particular, B cell lymphomas and leukemias.
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公开(公告)号：US10098951B2
公开(公告)日：2018-10-16
申请号：US15829793
申请日：2017-12-01
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： C07K16/00 , A61K39/395 , A61K35/17 , C12N15/62 , C07K14/725 , C07K16/28 , A61K38/00 , A61K39/00
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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