A glass sheet acquisition and positioning system and associated method are utilized in a glass sheet optical inspection system installed in-line in a glass sheet processing system. The acquisition and positioning system include an exterior support frame and a moveable glass sheet support frame connected to the exterior support frame such that the glass sheet support frame may be selectively positioned from first orientation whereby a glass sheet is removed from a conveyor and retained on the support frame, to a second orientation whereby the glass sheet is positioned for processing by the optical inspection system. The system may also include a glass sheet part identifier and a programmable control including logic for analyzing acquired image data and identifying the glass sheet as one of a set of known part types and thereafter securing and positioning the glass sheet on the glass sheet support frame based upon the part-shape analysis.