发明授权
- 专利标题： Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
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申请号： US16712951申请日： 2019-12-12
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公开(公告)号： US10889567B2公开(公告)日： 2021-01-12
- 发明人: Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
- 申请人： FORMA Therapeutics, Inc.
- 申请人地址： US MA Watertown
- 专利权人： FORMA Therapeutics, Inc.
- 当前专利权人： FORMA Therapeutics, Inc.
- 当前专利权人地址： US MA Watertown
- 代理机构： Choate, Hall & Stewart, LLP
- 代理商 John P. Rearick; Erica M. D'Amato
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; C07D471/04 ; A61P35/00 ; A61K31/47
摘要：
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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