A real-time system and method for personal air pollution exposure and inhaled dose management is described. A personal device (e.g., smartphone) determines personal exposure and inhaled dose metrics (e.g., daily accumulated dose), and compares daily histories of these metrics with personal health histories (e.g., self-reported daily asthma symptoms/inhaler use) to provide notifications when adverse health effects (e.g., asthma exacerbation) are likely to occur. The system notifications provide a personalized exposure/dose management tool by recommending behavioral changes to reduce exposure/dose (e.g., change time-location, time-physical activities, building operation). These behavioral changes are then used by the system to modify the real-time exposure and dose determined by the system.