Systems and methods to combine multiple voice activated audio input data packets that indicate sequence dependent operations are provided. A natural language processor component can receive first and second input audio signal from a client computing device, and can identify respective requests and corresponding trigger keywords. A direct action application programming interface (“API”) can generate respective action data structures, and can construct respective data transmissions including the respective action data structures. A thread optimization component can obtain data packets of the first data transmission, and can obtain data packets of the second data transmission. The thread optimization component can determine, based on a heuristic technique applied to the data packets of the respective data transmissions a sequence dependency parameter. The thread optimization component can merge, based on a comparison of the sequence dependency parameter with a threshold, the first and second data transmissions into a single thread.