In embodiments, a first 3D model of a patient's teeth based on first intraoral scan data taken at a first time is processed to recognize the teeth in the first 3D model. A second 3D model of the patient's teeth based on second intraoral scan data taken at a second time is processed to recognize the teeth in the second 3D model. The first 3D model is compared to the second 3D model and a plurality of AOIs in the second virtual 3D model representative of at least one of tooth wear, tooth breakage, tooth movement, gingival recession or gingival swelling are determined based on the comparison. The teeth recognized in the first 3D model are compared to the teeth recognized in the second 3D model, and one or more AOIs in the second virtual 3D model representative of tooth wear or tooth breakage are determined based on the comparison.