Systems and methods include providing vertical takeoff and landing (VTOL) aircraft with a cargo pod having a selectively inflatable bladder system that firmly secures a payload disposed within the cargo pod when the bladder system is pressurized. The bladder system also controls the location, position, and/or orientation of the payload in order to adjust, control, and/or maintain the center of gravity of the aircraft during flight. The aircraft includes an impact protection system that further pressurizes the bladder system to protect the payload and/or that disperses a flame-retardant fluid into the cargo pod to protect electrical components of the aircraft. The aircraft is fully autonomous and self-directed via a preprogrammed location-based guidance system to allow for accurate delivery of the payload to its intended destination. The bladder system is depressurized in response to a landing event to allow for e f the payload from the cargo pod.