- Patent Title: Polynucleotides encoding optimized variants of anti-VEGF antibodies
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Application No.: US16033353Application Date: 2018-07-12
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Publication No.: US10906968B2Publication Date: 2021-02-02
- Inventor: Patrick Koenig , Chingwei Vivian Lee , Karthikan Rajagopal , Amin Famili , Germaine Fuh
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Clark & Elbing LLP
- Agent Karen L. Elbing
- Main IPC: C12N15/10
- IPC: C12N15/10 ; C12N15/115 ; C07K16/22 ; A61K47/60 ; A61K47/61 ; A61K39/395 ; A61K47/34 ; C07K14/475 ; C07K16/44 ; C07K16/46 ; A61K39/00
Abstract:
The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.
Public/Granted literature
- US20190031750A1 OPTIMIZED VARIANTS OF ANTI-VEGF ANTIBODIES Public/Granted day:2019-01-31
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