- 专利标题： Oligonucleotides comprising acyclic and abasic nucleosides and analogs
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申请号： US13642772申请日： 2011-04-22
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公开(公告)号： US10913767B2公开(公告)日： 2021-02-09
- 发明人: Muthiah Manoharan , Kallanthottathil G. Rajeev , Jeremy Lackey , Narayanannair K. Jayaprakash
- 申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Jeremy Lackey , Narayanannair K. Jayaprakash
- 申请人地址： US MA Cambridge; US MA Cambridge; US MA Cambridge; US MA Cambridge
- 专利权人： Muthiah Manoharan,Kallanthottathil G. Rajeev,Jeremy Lackey,Narayanannair K. Jayaprakash
- 当前专利权人： Muthiah Manoharan,Kallanthottathil G. Rajeev,Jeremy Lackey,Narayanannair K. Jayaprakash
- 当前专利权人地址： US MA Cambridge; US MA Cambridge; US MA Cambridge; US MA Cambridge
- 代理机构： Cozen O'Connor
- 代理商 Jeffrey N. Townes
- 国际申请： PCT/US2011/033598 WO 20110422
- 国际公布： WO2011/133876 WO 20111027
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/00 ; C07F9/6512 ; C07F9/655 ; C07F9/6558 ; C07H19/20 ; C12N15/11
摘要：
This invention relates to an oligonucleotide comprising one or more abasic nucleoside monomers of formula V: These monomers are useful for modifying of oligonucleotides at one or more positions. This invention also relates to a method of inhibiting the expression of a target gene in a cell. The method comprises contacting the cell with an oligonucleotide having one or more of the above formula (V).
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