A heating, ventilation, and air conditioning (HVAC) system may be zoned into one or more zone. The HVAC system may include HVAC components, sensors, and one or more register vents that may include vent dampers (e.g., electronically controllable vent dampers or manually operated vent dampers). Opening and closing of the vent dampers may facilitate creating zones or sub-zones in the HVAC system configuration. An HVAC control system may receive a request for conditioned air in one or more of the zones, determine a damper setting for at least one of the vent dampers, communicate the determined damper setting to a vent damper or user interface, determine which HVAC components should be active, if any, and/or provide controls signals to activate or keep active the HVAC components that are determined to be active.