- 专利标题: Fused imidazoles as mIDH1 inhibitors
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申请号: US15746352申请日: 2016-07-14
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公开(公告)号: US10919862B2公开(公告)日: 2021-02-16
- 发明人: Olaf Panknin , Ingo Hartung , Hartmut Rehwinkel , Duy Nguyen , Ludwig Zorn , Petra Helfrich , Katja Zimmermann , Roland Neuhaus
- 申请人: BAYER PHARMA AKTIENGESELLSCHAFT
- 申请人地址: DE Berlin
- 专利权人: BAYER PHARMA AKTIENGESELLSCHAFT
- 当前专利权人: BAYER PHARMA AKTIENGESELLSCHAFT
- 当前专利权人地址: DE Berlin
- 代理机构: Morrison & Foerster LLP
- 优先权: EP15177743 20150721
- 国际申请: PCT/EP2016/066720 WO 20160714
- 国际公布: WO2017/012967 WO 20170126
- 主分类号: C07D235/30
- IPC分类号: C07D235/30 ; C07D471/04 ; A61P35/00 ; A61K31/4184 ; A61K31/437 ; A61K45/06 ; C12P17/10
摘要:
The present invention relates to compounds of general formula (I): in which R1, R2, R3, R4, R6, R7, R8, R9, R10, R11, R12, R13 and X are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
公开/授权文献
- US20180215717A1 FUSED IMIDAZOLES AS MIDH1 INHIBITORS 公开/授权日:2018-08-02
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