Power and performance of a multi-core system is managed dynamically by adjusting power table indices at runtime. Runtime statistics is measured, when an application is executed on a first core of a first type at a first operating point (OPP) in a first time period, and on a second core of a second core type at a second OPP in a second time period. A controller estimates, based on the runtime statistics, a first pair of indices associated with a first OPP for the first core and a second pair of indices associated with a second OPP for the second core. During runtime, the controller incorporates the first pair of indices and the second pair of indices into power table indices; and determines, from the power table indices, selected indices associated with a selected OPP of a core of a selected core type for executing the application.