- 专利标题： Substituted pyrazolopyrimidines as glucocerebrosidase activators
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申请号： US15983844申请日： 2018-05-18
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公开(公告)号： US10925874B2公开(公告)日： 2021-02-23
- 发明人: Juan Jose Marugan , Noel Southall , Ehud Goldin , Wei Zheng , Samarjit Patnaik , Ellen Sidransky , Omid Motabar , Wendy Westbroek
- 申请人： The United States of America, as Represented by the Secretary, Department of Health and Human Service
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America, as Represented by the Secretary, Department of Health and Human Service
- 当前专利权人： The United States of America, as Represented by the Secretary, Department of Health and Human Service
- 当前专利权人地址： US MD Bethesda
- 代理机构： Cantor Colburn LLP
- 主分类号： C07D487/02
- IPC分类号： C07D487/02 ; A61K31/519 ; A61P43/00 ; C07D487/04 ; A61K31/5377
摘要：
Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I) in which variables R1-R7 and X are described in the application.
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