专利检索 ap:("The United States of America, as Represented by the Secretary, Department of Health AND Human Service") AND inv:"Ehud Goldin" 第 1 页

1.

发明授权
Substituted pyrazolopyrimidines as glucocerebrosidase activators 有权

公开(公告)号：US10925874B2

公开(公告)日：2021-02-23

申请号：US15983844

申请日：2018-05-18

申请人： The United States of America, as Represented by the Secretary, Department of Health and Human Service

发明人： Juan Jose Marugan , Noel Southall , Ehud Goldin , Wei Zheng , Samarjit Patnaik , Ellen Sidransky , Omid Motabar , Wendy Westbroek

IPC分类号： C07D487/02 , A61K31/519 , A61P43/00 , C07D487/04 , A61K31/5377

摘要： Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I) in which variables R1-R7 and X are described in the application.