Examples described herein generally relate to a layered boundary interconnect in an integrated circuit (IC) and methods for operating such IC. In an example, an IC includes a programmable logic region, a plurality of input/output circuits, a plurality of hard block circuits, and a programmable native transmission network. The programmable native transmission network is connected to and between the plurality of input/output circuits and the plurality of hard block circuits. The plurality of hard block circuits is connected to and between the programmable native transmission network and the programmable logic region.