Invention Grant
- Patent Title: Cell populations, methods of transdifferentiation and methods of use thereof
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Application No.: US15961907Application Date: 2018-04-25
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Publication No.: US10947509B2Publication Date: 2021-03-16
- Inventor: Sarah Ferber
- Applicant: ORGENESIS LTD. , TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
- Applicant Address: IL Tel Aviv; IL Ramat Gan
- Assignee: ORGENESIS LTD.,TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
- Current Assignee: ORGENESIS LTD.,TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
- Current Assignee Address: IL Tel Aviv; IL Ramat Gan
- Agency: Pearl Cohen Zedek Latzer Baratz LLP
- Agent Mark S. Cohen
- Main IPC: C12N5/071
- IPC: C12N5/071 ; G01N33/50 ; A61K38/17 ; A61K35/407 ; A61K35/38
Abstract:
The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic β-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.
Public/Granted literature
- US20180340146A1 CELL POPULATIONS, METHODS OF TRANSDIFFERENTIATION AND METHODS OF USE THEREOF Public/Granted day:2018-11-29
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