-
公开(公告)号：US10179151B2
公开(公告)日：2019-01-15
申请号：US14983657
申请日：2015-12-30
Inventor： Sarah Ferber
Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
-
公开(公告)号：US20200297777A1
公开(公告)日：2020-09-24
申请号：US16836967
申请日：2020-04-01
Inventor： Sarah FERBER
Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
-
公开(公告)号：US10668107B2
公开(公告)日：2020-06-02
申请号：US16203654
申请日：2018-11-29
Inventor： Sarah Ferber
Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
-
公开(公告)号：US20180340146A1
公开(公告)日：2018-11-29
申请号：US15961907
申请日：2018-04-25
Inventor： Sarah FERBER
Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic β-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.
-
公开(公告)号：US10975354B2
公开(公告)日：2021-04-13
申请号：US16676481
申请日：2019-11-07
Inventor： Sarah Ferber
IPC: C12N5/071 , G01N33/543
Abstract: Disclosed herein are methods for manufacturing transdifferentiated populations of non-pancreatic human insulin producing cells, and methods for enriching populations of non-pancreatic β-cells for cells comprising an enriched capacity for transcription factor-induced transdifferentiation into a pancreatic β-cell phenotype and function.
-
Patent Agency Ranking
公开(公告)号：US10947509B2
公开(公告)日：2021-03-16
申请号：US15961907
申请日：2018-04-25
Inventor： Sarah Ferber
IPC: C12N5/071 , G01N33/50 , A61K38/17 , A61K35/407 , A61K35/38
Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic β-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.
-
公开(公告)号：US20190134097A1
公开(公告)日：2019-05-09
申请号：US16203654
申请日：2018-11-29
Inventor： Sarah FERBER
Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
-
公开(公告)号：US20160220616A1
公开(公告)日：2016-08-04
申请号：US14983657
申请日：2015-12-30
Inventor： Sarah Ferber
CPC classification number: A61K35/39 , A61K38/00 , C07K14/62 , C12N5/0676 , C12N15/09 , C12N15/63 , C12N15/86 , C12N2501/60 , C12N2506/14 , C12N2510/00 , C12N2710/10343
Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
Abstract translation: 本文公开了一种从非胰腺β-细胞制备人胰岛素生成细胞群体的方法，其中所产生的胰岛素产生细胞具有增加的胰岛素含量或增加的葡萄糖调节胰岛素的分泌，或两者的组合。
-
公开(公告)号：US11617769B2
公开(公告)日：2023-04-04
申请号：US16836967
申请日：2020-04-01
Inventor： Sarah Ferber
Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
-
公开(公告)号：US09982236B2
公开(公告)日：2018-05-29
申请号：US14897262
申请日：2014-06-13
Inventor： Sarah Ferber
CPC classification number: C12N5/0676 , A61K35/38 , A61K35/407 , A61K38/1709 , C12N2501/60 , C12N2506/14 , C12N2510/00 , C12N2710/10343 , C12N2830/30
Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic β-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.021 seconds)
